This study will evaluate the efficacy, safety, tolerability and pharmacokinetics of JTT-861 administered once daily for 12 weeks in subjects with heart failure with reduced ejection fraction (HFrEF) w ...

Condition: Chronic Heart Failure

Establish a cardiovascular biomarker profile to help screening for congenital heart disease in infants and children as well as use non-invasive cardiac imaging in combination with such profiling to be ...

Condition: Heart Disease Congenital
Ventricular Septal Defect
Atrial Septal Defect
Patent Ductus

The ENGAGE-HF mobile application tracks three key features over time: (1) heart failure health status, (2) vital signs (e.g., blood pressure, heart rate) and weight, and (3) the quality of heart failu ...

Condition: Heart Failure

Postoperative gastrointestinal bleeding (GIB) after open-heart surgery is associated with increased mortality, yet the prognostic impact of endoscopic intervention remains uncertain. We conducted a si

Whether links between adulthood stressful life events (SLEs) and heart disease are comparable across countries—and whether they follow a dose–response pattern—remains uncertain. We harmonized exposure

Infants undergoing congenital heart surgery with cardiopulmonary bypass (CPB) are at high risk for perioperative neurological injury, and early postoperative cerebral desaturation events (CDEs) remain